The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution

The immune system can recognize and attack cancer cells, especially those with a high load of mutation-induced neoantigens. Such neoantigens are abundant in DNA mismatch repair (MMR)-deficient, microsatellite-unstable (MSI) cancers. MMR deficiency leads to insertion/deletion (indel) mutations at cod...

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Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Ballhausen, Alexej, Przybilla, Moritz Jakob, Jendrusch, Michael, Haupt, Saskia, Pfaffendorf, Elisabeth, Seidler, Florian, Witt, Johannes, Hernandez Sanchez, Alejandro, Urban, Katharina, Draxlbauer, Markus, Krausert, Sonja, Ahadova, Aysel, Kalteis, Martin Simon, Pfuderer, Pauline L., Heid, Daniel, Stichel, Damian, Gebert, Johannes, Bonsack, Maria, Schott, Sarah, Bläker, Hendrik, Seppälä, Toni, Mecklin, Jukka-Pekka, Ten Broeke, Sanne, Nielsen, Maartje, Heuveline, Vincent, Krzykalla, Julia, Benner, Axel, Riemer, Angelika Beate, von Knebel Doeberitz, Magnus, Kloor, Matthias
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2020
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7506541/
https://ncbi.nlm.nih.gov/pubmed/32958755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18514-5
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