High endothelial venules are associated with microsatellite instability, hereditary background and immune evasion in colorectal cancer

BACKGROUND: Microsatellite-unstable (MSI) tumours show a high load of mutational neoantigens, as a consequence of DNA mismatch repair deficiency. Consequently, MSI tumours commonly present with dense immune infiltration and develop immune evasion mechanisms. Whether improved lymphocyte recruitment c...

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Bibliografiset tiedot
Julkaisussa:Br J Cancer
Päätekijät: Pfuderer, Pauline L., Ballhausen, Alexej, Seidler, Florian, Stark, Hans-Jürgen, Grabe, Niels, Frayling, Ian M., Ager, Ann, von Knebel Doeberitz, Magnus, Kloor, Matthias, Ahadova, Aysel
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6738093/
https://ncbi.nlm.nih.gov/pubmed/31358939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-019-0514-6
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