Beta-2-microglobulin Mutations Are Linked to a Distinct Metastatic Pattern and a Favorable Outcome in Microsatellite-Unstable Stage IV Gastrointestinal Cancers

Immune checkpoint blockade (ICB) shows remarkable clinical effects in patients with metastatic microsatellite-unstable (MSI) cancer. However, markers identifying potential non-responders are missing. We examined the prevalence of Beta-2-microglobulin (B2M) mutations, a common immune evasion mechanis...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Busch, Elena, Ahadova, Aysel, Kosmalla, Kosima, Bohaumilitzky, Lena, Pfuderer, Pauline L., Ballhausen, Alexej, Witt, Johannes, Wittemann, Jan-Niklas, Bläker, Hendrik, Holinski-Feder, Elke, Jäger, Dirk, von Knebel Doeberitz, Magnus, Haag, Georg Martin, Kloor, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8219238/
https://ncbi.nlm.nih.gov/pubmed/34168989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.669774
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