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PRIMA-1(met) induces autophagy in colorectal cancer cells through upregulation of the mTOR/AMPK-ULK1-Vps34 signaling cascade
p53-reactivation and induction of massive apoptosis-1, APR-017 methylated (PRIMA-1(met); APR246) targets mutant p53 to restore its wild-type structure and function. It was previously demonstrated that PRIMA-1(met) effectively inhibited the growth of colorectal cancer (CRC) cells in a p53-independent...
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| Pubblicato in: | Oncol Rep |
|---|---|
| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
D.A. Spandidos
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8025076/ https://ncbi.nlm.nih.gov/pubmed/33846805 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/or.2021.8037 |
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