Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis

Functional contributions of individual cellular components of the bone-marrow microenvironment to myelofibrosis (MF) in patients with myeloproliferative neoplasms (MPNs) are incompletely understood. We aimed to generate a comprehensive map of the stroma in MPNs/MFs on a single-cell level in murine m...

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Publicado en:Cell Stem Cell
Autores principales: Leimkühler, Nils B., Gleitz, Hélène F.E., Ronghui, Li, Snoeren, Inge A.M., Fuchs, Stijn N.R., Nagai, James S., Banjanin, Bella, Lam, King H., Vogl, Thomas, Kuppe, Christoph, Stalmann, Ursula S.A., Büsche, Guntram, Kreipe, Hans, Gütgemann, Ines, Krebs, Philippe, Banz, Yara, Boor, Peter, Tai, Evelyn Wing-Yin, Brümmendorf, Tim H., Koschmieder, Steffen, Crysandt, Martina, Bindels, Eric, Kramann, Rafael, Costa, Ivan G., Schneider, Rebekka K.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cell Press 2021
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8024900/
https://ncbi.nlm.nih.gov/pubmed/33301706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2020.11.004
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