An experimental strategy to probe Gq contribution to signal transduction in living cells

Heterotrimeric G protein subunits Gαq and Gα11 are inhibited by two cyclic depsipeptides, FR900359 (FR) and YM-254890 (YM), both of which are being used widely to implicate Gq/11 proteins in the regulation of diverse biological processes. An emerging major research question therefore is whether the...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Patt, Julian, Alenfelder, Judith, Pfeil, Eva Marie, Voss, Jan Hendrik, Merten, Nicole, Eryilmaz, Funda, Heycke, Nina, Rick, Uli, Inoue, Asuka, Kehraus, Stefan, Deupi, Xavier, Müller, Christa E., König, Gabriele M., Crüsemann, Max, Kostenis, Evi
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2021
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8024710/
https://ncbi.nlm.nih.gov/pubmed/33639168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100472
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