Vangl2 promotes the formation of long cytonemes to enable distant Wnt/β-catenin signaling

Wnt signaling regulates cell proliferation and cell differentiation as well as migration and polarity during development. However, it is still unclear how the Wnt ligand distribution is precisely controlled to fulfil these functions. Here, we show that the planar cell polarity protein Vangl2 regulat...

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Udgivet i:Nat Commun
Main Authors: Brunt, Lucy, Greicius, Gediminas, Rogers, Sally, Evans, Benjamin D., Virshup, David M., Wedgwood, Kyle C. A., Scholpp, Steffen
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8024337/
https://ncbi.nlm.nih.gov/pubmed/33824332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22393-9
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