Lipocalin 2 mediates appetite suppression during pancreatic cancer cachexia

Lipocalin 2 (LCN2) was recently identified as an endogenous ligand of the type 4 melanocortin receptor (MC4R), a critical regulator of appetite. However, it remains unknown if this molecule influences appetite during cancer cachexia, a devastating clinical entity characterized by decreased nutrition...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Olson, Brennan, Zhu, Xinxia, Norgard, Mason A., Levasseur, Peter R., Butler, John T., Buenafe, Abigail, Burfeind, Kevin G., Michaelis, Katherine A., Pelz, Katherine R., Mendez, Heike, Edwards, Jared, Krasnow, Stephanie M., Grossberg, Aaron J., Marks, Daniel L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8024334/
https://ncbi.nlm.nih.gov/pubmed/33824339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22361-3
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