Shared recognition of citrullinated tenascin-C peptides by T and B cells in rheumatoid arthritis

Tenascin-C (TNC), an extracellular matrix protein that has proinflammatory properties, is a recently described antibody target in rheumatoid arthritis (RA). In this study, we utilized a systematic discovery process and identified 5 potentially novel citrullinated TNC (cit-TNC) T cell epitopes. CD4(+...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Song, Jing, Schwenzer, Anja, Wong, Alicia, Turcinov, Sara, Rims, Cliff, Martinez, Lorena Rodriguez, Arribas-Layton, David, Gerstner, Christina, Muir, Virginia S., Midwood, Kim S., Malmström, Vivianne, James, Eddie A., Buckner, Jane H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8021118/
https://ncbi.nlm.nih.gov/pubmed/33507879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.145217
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