Identification of an immunodominant peptide from citrullinated tenascin-C as a major target for autoantibodies in rheumatoid arthritis

OBJECTIVES: We investigated whether citrullinated tenascin-C (cTNC), an extracellular matrix protein expressed at high levels in the joints of patients with rheumatoid arthritis (RA), is a target for the autoantibodies in RA. METHODS: Citrullinated sites were mapped by mass spectrometry in the fibri...

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Detalhes bibliográficos
Publicado no:Ann Rheum Dis
Main Authors: Schwenzer, Anja, Jiang, Xia, Mikuls, Ted R, Payne, Jeffrey B, Sayles, Harlan R, Quirke, Anne-Marie, Kessler, Benedikt M, Fischer, Roman, Venables, Patrick J, Lundberg, Karin, Midwood, Kim S
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2016
Assuntos:
Basic and Translational Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5036245/
https://ncbi.nlm.nih.gov/pubmed/26659718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2015-208495
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