Active and Passive Destabilization of G-Quadruplex DNA by the Telomere POT1-TPP1 Complex

Chromosome ends are protected by guanosine-rich telomere DNA that forms stable G-quadruplex (G4) structures. The heterodimeric POT1-TPP1 complex interacts specifically with telomere DNA to shield it from illicit DNA damage repair and to resolve secondary structure that impedes telomere extension. Th...

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Bibliografske podrobnosti
izdano v:J Mol Biol
Main Authors: Xu, Mengyuan, Axhemi, Armend, Malgowska, Magdalena, Chen, Yinghua, Leonard, Daniel, Srinivasan, Sukanya, Jankowsky, Eckhard, Taylor, Derek J.
Format: Artigo
Jezik:Inglês
Izdano: 2021
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8020995/
https://ncbi.nlm.nih.gov/pubmed/33549587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2021.166846
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