Ultrapotent bispecific antibodies neutralize emerging SARS-CoV-2 variants

The emergence of SARS-CoV-2 variants that threaten the efficacy of existing vaccines and therapeutic antibodies underscores the urgent need for new antibody-based tools that potently neutralize variants by targeting multiple sites of the spike protein. We isolated 216 monoclonal antibodies targeting...

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Publicat a:bioRxiv
Autors principals: Cho, Hyeseon, Gonzales-Wartz, Kristina Kay, Huang, Deli, Yuan, Meng, Peterson, Mary, Liang, Janie, Beutler, Nathan, Torres, Jonathan L., Cong, Yu, Postnikova, Elena, Bangaru, Sandhya, Talana, Chloe Adrienna, Shi, Wei, Yang, Eun Sung, Zhang, Yi, Leung, Kwanyee, Wang, Lingshu, Peng, Linghang, Skinner, Jeff, Li, Shanping, Wu, Nicholas C., Liu, Hejun, Dacon, Cherrelle, Moyer, Thomas, Cohen, Melanie, Zhao, Ming, Lee, F. Eun-Hyung, Weinberg, Rona S., Douagi, Iyadh, Gross, Robin, Schmaljohn, Connie, Pegu, Amarendra, Mascola, John R., Holbrook, Michael, Nemazee, David, Rogers, Thomas F., Ward, Andrew B., Wilson, Ian A., Crompton, Peter D., Tan, Joshua
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8020967/
https://ncbi.nlm.nih.gov/pubmed/33821267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.04.01.437942
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