Ultrapotent bispecific antibodies neutralize emerging SARS-CoV-2 variants

The emergence of SARS-CoV-2 variants that threaten the efficacy of existing vaccines and therapeutic antibodies underscores the urgent need for new antibody-based tools that potently neutralize variants by targeting multiple sites of the spike protein. We isolated 216 monoclonal antibodies targeting...

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Publicado no:bioRxiv
Main Authors: Cho, Hyeseon, Gonzales-Wartz, Kristina Kay, Huang, Deli, Yuan, Meng, Peterson, Mary, Liang, Janie, Beutler, Nathan, Torres, Jonathan L., Cong, Yu, Postnikova, Elena, Bangaru, Sandhya, Talana, Chloe Adrienna, Shi, Wei, Yang, Eun Sung, Zhang, Yi, Leung, Kwanyee, Wang, Lingshu, Peng, Linghang, Skinner, Jeff, Li, Shanping, Wu, Nicholas C., Liu, Hejun, Dacon, Cherrelle, Moyer, Thomas, Cohen, Melanie, Zhao, Ming, Lee, F. Eun-Hyung, Weinberg, Rona S., Douagi, Iyadh, Gross, Robin, Schmaljohn, Connie, Pegu, Amarendra, Mascola, John R., Holbrook, Michael, Nemazee, David, Rogers, Thomas F., Ward, Andrew B., Wilson, Ian A., Crompton, Peter D., Tan, Joshua
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8020967/
https://ncbi.nlm.nih.gov/pubmed/33821267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.04.01.437942
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