Urantide: an ultrapotent urotensin II antagonist peptide in the rat aorta

In this study we describe the ability of two human urotensin-II (hU-II) derivatives [Pen(5),Orn(8)]hU-II(4–11) and [Pen(5),DTrp(7),Orn(8)]hU-II(4–11) (urantide) to block hU-II-induced contractions in the rat isolated thoracic aorta. Both compounds competitively antagonized hU-II- induced effects wit...

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Bibliografiske detaljer
Main Authors: Patacchini, Riccardo, Santicioli, Paolo, Giuliani, Sandro, Grieco, Paolo, Novellino, Ettore, Rovero, Paolo, Maggi, Carlo Alberto
Format: Artigo
Sprog:Inglês
Udgivet: 2003
Fag:
Special Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1574141/
https://ncbi.nlm.nih.gov/pubmed/14645137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705555
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