Role of Electrostatic Hotspots in the Selectivity of Complement Control Proteins Toward Human and Bovine Complement Inhibition

Poxviruses are dangerous pathogens, which can cause fatal infection in unvaccinated individuals. The causative agent of smallpox in humans, variola virus, is closely related to the bovine vaccinia virus, yet the molecular basis of their selectivity is currently incompletely understood. Here, we exam...

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Veröffentlicht in:Front Mol Biosci
Hauptverfasser: Narkhede, Yogesh B., Gautam, Avneesh K., Hsu, Rohaine V., Rodriguez, Wilson, Zewde, Nehemiah T., Harrison, Reed E. S., Arantes, Pablo R., Gaieb, Zied, Gorham, Ronald D., Kieslich, Chris, Morikis, Dimitrios, Sahu, Arvind, Palermo, Giulia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Molecular Biosciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8020814/
https://ncbi.nlm.nih.gov/pubmed/33829039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2021.618068
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