CD4 receptor diversity represents an ancient protection mechanism against primate lentiviruses

Infection with human and simian immunodeficiency viruses (HIV/SIV) requires binding of the viral envelope glycoprotein (Env) to the host protein CD4 on the surface of immune cells. Although invariant in humans, the Env binding domain of the chimpanzee CD4 is highly polymorphic, with nine coding vari...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Proc Natl Acad Sci U S A
मुख्य लेखकों: Russell, Ronnie M., Bibollet-Ruche, Frederic, Liu, Weimin, Sherrill-Mix, Scott, Li, Yingying, Connell, Jesse, Loy, Dorothy E., Trimboli, Stephanie, Smith, Andrew G., Avitto, Alexa N., Gondim, Marcos V. P., Plenderleith, Lindsey J., Wetzel, Katherine S., Collman, Ronald G., Ayouba, Ahidjo, Esteban, Amandine, Peeters, Martine, Kohler, William J., Miller, Richard A., François-Souquiere, Sandrine, Switzer, William M., Hirsch, Vanessa M., Marx, Preston A., Piel, Alex K., Stewart, Fiona A., Georgiev, Alexander V., Sommer, Volker, Bertolani, Paco, Hart, John A., Hart, Terese B., Shaw, George M., Sharp, Paul M., Hahn, Beatrice H.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: National Academy of Sciences 2021
विषय:
Biological Sciences
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC8020793/
https://ncbi.nlm.nih.gov/pubmed/33771926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2025914118
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