CD4 receptor diversity represents an ancient protection mechanism against primate lentiviruses

Infection with human and simian immunodeficiency viruses (HIV/SIV) requires binding of the viral envelope glycoprotein (Env) to the host protein CD4 on the surface of immune cells. Although invariant in humans, the Env binding domain of the chimpanzee CD4 is highly polymorphic, with nine coding vari...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Russell, Ronnie M., Bibollet-Ruche, Frederic, Liu, Weimin, Sherrill-Mix, Scott, Li, Yingying, Connell, Jesse, Loy, Dorothy E., Trimboli, Stephanie, Smith, Andrew G., Avitto, Alexa N., Gondim, Marcos V. P., Plenderleith, Lindsey J., Wetzel, Katherine S., Collman, Ronald G., Ayouba, Ahidjo, Esteban, Amandine, Peeters, Martine, Kohler, William J., Miller, Richard A., François-Souquiere, Sandrine, Switzer, William M., Hirsch, Vanessa M., Marx, Preston A., Piel, Alex K., Stewart, Fiona A., Georgiev, Alexander V., Sommer, Volker, Bertolani, Paco, Hart, John A., Hart, Terese B., Shaw, George M., Sharp, Paul M., Hahn, Beatrice H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2021
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8020793/
https://ncbi.nlm.nih.gov/pubmed/33771926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2025914118
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