Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis

Osteoarthritis (OA) is a painful and debilitating condition of synovial joints without any disease-modifying therapies [A. M. Valdes, T. D. Spector, Nat. Rev. Rheumatol. 7, 23–32 (2011)]. We previously identified mechanosensitive PIEZO channels, PIEZO1 and PIEZO2, both expressed in articular cartila...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Lee, Whasil, Nims, Robert J., Savadipour, Alireza, Zhang, Qiaojuan, Leddy, Holly A., Liu, Fang, McNulty, Amy L., Chen, Yong, Guilak, Farshid, Liedtke, Wolfgang B.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2021
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8020656/
https://ncbi.nlm.nih.gov/pubmed/33758095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2001611118
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