Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage

Diarthrodial joints are essential for load bearing and locomotion. Physiologically, articular cartilage sustains millions of cycles of mechanical loading. Chondrocytes, the cells in cartilage, regulate their metabolic activities in response to mechanical loading. Pathological mechanical stress can l...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Lee, Whasil, Leddy, Holly A., Chen, Yong, Lee, Suk Hee, Zelenski, Nicole A., McNulty, Amy L., Wu, Jason, Beicker, Kellie N., Coles, Jeffrey, Zauscher, Stefan, Grandl, Jörg, Sachs, Frederick, Guilak, Farshid, Liedtke, Wolfgang B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4250098/
https://ncbi.nlm.nih.gov/pubmed/25385580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1414298111
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