Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage

Diarthrodial joints are essential for load bearing and locomotion. Physiologically, articular cartilage sustains millions of cycles of mechanical loading. Chondrocytes, the cells in cartilage, regulate their metabolic activities in response to mechanical loading. Pathological mechanical stress can l...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Lee, Whasil, Leddy, Holly A., Chen, Yong, Lee, Suk Hee, Zelenski, Nicole A., McNulty, Amy L., Wu, Jason, Beicker, Kellie N., Coles, Jeffrey, Zauscher, Stefan, Grandl, Jörg, Sachs, Frederick, Guilak, Farshid, Liedtke, Wolfgang B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2014
Schlagworte:
PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4250098/
https://ncbi.nlm.nih.gov/pubmed/25385580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1414298111
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