Naturally Occurring Point Mutation Cys460Trp Located in the I-EGF1 Domain of Integrin β3 Alters the Binding of Some anti-HPA-1a Antibodies

BACKGROUND: Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is caused by the destruction of platelets in the fetus or newborn by maternal platelet alloantibodies (Abs), mostly against human platelet antigen (HPA)-1a. Recent studies indicate that two anti-HPA-subtypes exist: type I reacts with...

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Publicado no:Transfusion
Main Authors: Holzwarth, Sarah Theresa, Bayat, Behnaz, Zhu, Jieqing, Phuangtham, Roongaroon, Fischer, Lars, Boeckelmann, Doris, Roeder, Lida, Berghöfer, Heike, Schmidt, Silke, Bein, Gregor, Santoso, Sentot
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8020566/
https://ncbi.nlm.nih.gov/pubmed/32770549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/trf.15960
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