Inhibition of HPA-1a alloantibody-mediated platelet destruction by a deglycosylated anti–HPA-1a monoclonal antibody in mice: toward targeted treatment of fetal-alloimmune thrombocytopenia

Fetal/neonatal alloimmune thrombocytopenia (FNAIT) is often caused by maternal alloantibodies against the human platelet antigen (HPA)–1a, which opsonizes fetal platelets (PLTs). Subsequent PLT destruction is mediated via the Fc part of the alloantibodies. The monoclonal antibody (mAb) SZ21 binds to...

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Detalhes bibliográficos
Main Authors: Bakchoul, Tamam, Greinacher, Andreas, Sachs, Ulrich J., Krautwurst, Annika, Renz, Harald, Harb, Habi, Bein, Gregor, Newman, Peter J., Santoso, Sentot
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Plenary Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3716199/
https://ncbi.nlm.nih.gov/pubmed/23645838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-11-468561
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