Inhibition of HPA-1a alloantibody-mediated platelet destruction by a deglycosylated anti–HPA-1a monoclonal antibody in mice: toward targeted treatment of fetal-alloimmune thrombocytopenia

Fetal/neonatal alloimmune thrombocytopenia (FNAIT) is often caused by maternal alloantibodies against the human platelet antigen (HPA)–1a, which opsonizes fetal platelets (PLTs). Subsequent PLT destruction is mediated via the Fc part of the alloantibodies. The monoclonal antibody (mAb) SZ21 binds to...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Bakchoul, Tamam, Greinacher, Andreas, Sachs, Ulrich J., Krautwurst, Annika, Renz, Harald, Harb, Habi, Bein, Gregor, Newman, Peter J., Santoso, Sentot
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Hematology 2013
Ämnen:
Plenary Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3716199/
https://ncbi.nlm.nih.gov/pubmed/23645838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-11-468561
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk