Recombinant HPA-1a antibody therapy for treatment of fetomaternal alloimmune thrombocytopenia: proof of principle in human volunteers

Fetomaternal alloimmune thrombocytopenia, caused by the maternal generation of antibodies against fetal human platelet antigen-1a (HPA-1a), can result in intracranial hemorrhage and intrauterine death. We have developed a therapeutic human recombinant high-affinity HPA-1a antibody (B2G1Δnab) that co...

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Detalhes bibliográficos
Main Authors: Ghevaert, Cedric, Herbert, Nina, Hawkins, Louise, Grehan, Nicola, Cookson, Philip, Garner, Steve F., Crisp-Hihn, Abigail, Lloyd-Evans, Paul, Evans, Amanda, Balan, Kottekkattu, Ouwehand, Willem H., Armour, Kathryn L., Clark, Mike R., Williamson, Lorna M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Plenary Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3716198/
https://ncbi.nlm.nih.gov/pubmed/23656729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-02-481887
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