α-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss

Synaptic and neuronal loss are major neuropathological characteristics of Parkinson's disease. Misfolded protein aggregates in the form of Lewy bodies, comprised mainly of α-synuclein (αSyn), are associated with disease progression, and have also been linked to other neurodegenerative diseases,...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Trudler, Dorit, Sanz-Blasco, Sara, Eisele, Yvonne S., Ghatak, Swagata, Bodhinathan, Karthik, Akhtar, Mohd Waseem, Lynch, William P., Piña-Crespo, Juan C., Talantova, Maria, Kelly, Jeffery W., Lipton, Stuart A.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8018774/
https://ncbi.nlm.nih.gov/pubmed/33483428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1871-20.2020
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