Heparanome-Mediated Rescue of Oligodendrocyte Progenitor Quiescence following Inflammatory Demyelination

The proinflammatory cytokine IFN-γ, which is chronically elevated in multiple sclerosis, induces pathologic quiescence in human oligodendrocyte progenitor cells (OPCs) via upregulation of the transcription factor PRRX1. In this study using animals of both sexes, we investigated the role of heparan s...

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Publicat a:J Neurosci
Autors principals: Saraswat, Darpan, Welliver, R. Ross, Ravichandar, Roopa, Tripathi, Ajai, Polanco, Jessie J., Broome, Jacqueline, Hurley, Edward, Dutta, Ranjan, Feltri, M. Laura, Sim, Fraser J.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2021
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8018763/
https://ncbi.nlm.nih.gov/pubmed/33472827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0580-20.2021
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