Heparanome-Mediated Rescue of Oligodendrocyte Progenitor Quiescence following Inflammatory Demyelination

The proinflammatory cytokine IFN-γ, which is chronically elevated in multiple sclerosis, induces pathologic quiescence in human oligodendrocyte progenitor cells (OPCs) via upregulation of the transcription factor PRRX1. In this study using animals of both sexes, we investigated the role of heparan s...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Saraswat, Darpan, Welliver, R. Ross, Ravichandar, Roopa, Tripathi, Ajai, Polanco, Jessie J., Broome, Jacqueline, Hurley, Edward, Dutta, Ranjan, Feltri, M. Laura, Sim, Fraser J.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8018763/
https://ncbi.nlm.nih.gov/pubmed/33472827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0580-20.2021
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