Overcoming the inhibitory microenvironment surrounding oligodendrocyte progenitor cells following experimental demyelination

Chronic demyelination in the human CNS is characterized by an inhibitory microenvironment that impairs recruitment and differentiation of oligodendrocyte progenitor cells (OPCs) leading to failed remyelination and axonal atrophy. By network-based transcriptomics, we identified sulfatase 2 (Sulf2) mR...

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Publicat a:Nat Commun
Autors principals: Saraswat, Darpan, Shayya, Hani J., Polanco, Jessie J., Tripathi, Ajai, Welliver, R. Ross, Pol, Suyog U., Seidman, Richard A., Broome, Jacqueline E., O’Bara, Melanie A., van Kuppervelt, Toin H., Phillips, Joanna J., Dutta, Ranjan, Sim, Fraser J.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7998003/
https://ncbi.nlm.nih.gov/pubmed/33772011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22263-4
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