Overcoming the inhibitory microenvironment surrounding oligodendrocyte progenitor cells following experimental demyelination

Chronic demyelination in the human CNS is characterized by an inhibitory microenvironment that impairs recruitment and differentiation of oligodendrocyte progenitor cells (OPCs) leading to failed remyelination and axonal atrophy. By network-based transcriptomics, we identified sulfatase 2 (Sulf2) mR...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Saraswat, Darpan, Shayya, Hani J., Polanco, Jessie J., Tripathi, Ajai, Welliver, R. Ross, Pol, Suyog U., Seidman, Richard A., Broome, Jacqueline E., O’Bara, Melanie A., van Kuppervelt, Toin H., Phillips, Joanna J., Dutta, Ranjan, Sim, Fraser J.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7998003/
https://ncbi.nlm.nih.gov/pubmed/33772011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22263-4
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