Heparanome-Mediated Rescue of Oligodendrocyte Progenitor Quiescence following Inflammatory Demyelination

The proinflammatory cytokine IFN-γ, which is chronically elevated in multiple sclerosis, induces pathologic quiescence in human oligodendrocyte progenitor cells (OPCs) via upregulation of the transcription factor PRRX1. In this study using animals of both sexes, we investigated the role of heparan s...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Neurosci
Prif Awduron: Saraswat, Darpan, Welliver, R. Ross, Ravichandar, Roopa, Tripathi, Ajai, Polanco, Jessie J., Broome, Jacqueline, Hurley, Edward, Dutta, Ranjan, Feltri, M. Laura, Sim, Fraser J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Society for Neuroscience 2021
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8018763/
https://ncbi.nlm.nih.gov/pubmed/33472827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0580-20.2021
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