Cyclovirobuxine D Induces Apoptosis and Mitochondrial Damage in Glioblastoma Cells Through ROS-Mediated Mitochondrial Translocation of Cofilin

BACKGROUND: Cyclovirobuxine D (CVBD), a steroidal alkaloid, has multiple pharmacological activities, including anti-cancer activity. However, the anti-cancer effect of CVBD on glioblastoma (GBM) has seldom been investigated. This study explores the activity of CVBD in inducing apoptosis of GBM cells...

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Vydáno v:Front Oncol
Hlavní autoři: Zhang, Lin, Fu, Ruoqiu, Duan, Dongyu, Li, Ziwei, Li, Bin, Ming, Yue, Li, Li, Ni, Rui, Chen, Jianhong
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Oncology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8018288/
https://ncbi.nlm.nih.gov/pubmed/33816313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.656184
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