Pathophysiological Relevance of Renal Medullary Conditions on the Behaviour of Red Cells From Patients With Sickle Cell Anaemia

Red cells from patients with sickle cell anaemia (SCA) contain the abnormal haemoglobin HbS. Under hypoxic conditions, HbS polymerises and causes red cell sickling, a rise in intracellular Ca(2+) and exposure of phosphatidylserine (PS). These changes make sickle cells sticky and liable to lodge in t...

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Bibliografiske detaljer
Udgivet i:Front Physiol
Main Authors: Lu, David C.-Y., Wadud, Rasiqh, Hannemann, Anke, Rees, David C., Brewin, John N., Gibson, John Stanley
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Physiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8017214/
https://ncbi.nlm.nih.gov/pubmed/33815154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2021.653545
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