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Pathophysiological Relevance of Renal Medullary Conditions on the Behaviour of Red Cells From Patients With Sickle Cell Anaemia

Red cells from patients with sickle cell anaemia (SCA) contain the abnormal haemoglobin HbS. Under hypoxic conditions, HbS polymerises and causes red cell sickling, a rise in intracellular Ca(2+) and exposure of phosphatidylserine (PS). These changes make sickle cells sticky and liable to lodge in t...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Lu, David C.-Y., Wadud, Rasiqh, Hannemann, Anke, Rees, David C., Brewin, John N., Gibson, John Stanley
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8017214/
https://ncbi.nlm.nih.gov/pubmed/33815154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2021.653545
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