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Discovery of a Remarkable Methyl Shift Effect in the Vanilloid Activity of Triterpene Amides

[Image: see text] As part of a study on triterpenoid conjugates, the dietary pentacyclic triterpenoids oleanolic (2a) and ursolic acids (3a) were coupled with vanillamine, and the resulting amides (2b and 3b, respectively) were assayed for activity on the vanilloid receptor TRPV1. Despite a structur...

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Detalhes bibliográficos
Publicado no:J Nat Prod
Main Authors: Vitale, Rosa Maria, Avonto, Cristina, Del Prete, Danilo, Moriello, Aniello Schiano, Amodeo, Pietro, Appendino, Giovanni, De Petrocellis, Luciano
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society and American Society of Pharmacognosy 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8016363/
https://ncbi.nlm.nih.gov/pubmed/33136399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jnatprod.0c00639
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