A flexible repertoire of transcription factor binding sites and a diversity threshold determines enhancer activity in embryonic stem cells

Transcriptional enhancers are critical for development and phenotype evolution and are often mutated in disease contexts; however, even in well-studied cell types, the sequence code conferring enhancer activity remains unknown. To examine the enhancer regulatory code for pluripotent stem cells, we i...

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Detalhes bibliográficos
Publicado no:Genome Res
Main Authors: Singh, Gurdeep, Mullany, Shanelle, Moorthy, Sakthi D., Zhang, Richard, Mehdi, Tahmid, Tian, Ruxiao, Duncan, Andrew G., Moses, Alan M., Mitchell, Jennifer A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8015845/
https://ncbi.nlm.nih.gov/pubmed/33712417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.272468.120
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