Identification and characterization of conserved noncoding cis-regulatory elements that impact Mecp2 expression and neurological functions

While changes in MeCP2 dosage cause Rett syndrome (RTT) and MECP2 duplication syndrome (MDS), its transcriptional regulation is poorly understood. Here, we identified six putative noncoding regulatory elements of Mecp2, two of which are conserved in humans. Upon deletion in mice and human iPSC-deriv...

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Dades bibliogràfiques
Publicat a:Genes Dev
Autors principals: Shao, Yingyao, Bajikar, Sameer S., Tirumala, Harini P., Gutierrez, Manuel Cantu, Wythe, Joshua D., Zoghbi, Huda Y.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2021
Matèries:
Research Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8015713/
https://ncbi.nlm.nih.gov/pubmed/33737384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.345397.120
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