Identification and characterization of conserved noncoding cis-regulatory elements that impact Mecp2 expression and neurological functions

While changes in MeCP2 dosage cause Rett syndrome (RTT) and MECP2 duplication syndrome (MDS), its transcriptional regulation is poorly understood. Here, we identified six putative noncoding regulatory elements of Mecp2, two of which are conserved in humans. Upon deletion in mice and human iPSC-deriv...

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Bibliografiske detaljer
Udgivet i:Genes Dev
Main Authors: Shao, Yingyao, Bajikar, Sameer S., Tirumala, Harini P., Gutierrez, Manuel Cantu, Wythe, Joshua D., Zoghbi, Huda Y.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2021
Fag:
Research Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8015713/
https://ncbi.nlm.nih.gov/pubmed/33737384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.345397.120
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