Identification and characterization of conserved noncoding cis-regulatory elements that impact Mecp2 expression and neurological functions

While changes in MeCP2 dosage cause Rett syndrome (RTT) and MECP2 duplication syndrome (MDS), its transcriptional regulation is poorly understood. Here, we identified six putative noncoding regulatory elements of Mecp2, two of which are conserved in humans. Upon deletion in mice and human iPSC-deriv...

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Dettagli Bibliografici
Pubblicato in:Genes Dev
Autori principali: Shao, Yingyao, Bajikar, Sameer S., Tirumala, Harini P., Gutierrez, Manuel Cantu, Wythe, Joshua D., Zoghbi, Huda Y.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2021
Soggetti:
Research Communication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8015713/
https://ncbi.nlm.nih.gov/pubmed/33737384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.345397.120
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