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Identification and characterization of conserved noncoding cis-regulatory elements that impact Mecp2 expression and neurological functions
While changes in MeCP2 dosage cause Rett syndrome (RTT) and MECP2 duplication syndrome (MDS), its transcriptional regulation is poorly understood. Here, we identified six putative noncoding regulatory elements of Mecp2, two of which are conserved in humans. Upon deletion in mice and human iPSC-deriv...
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| Publicado no: | Genes Dev |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8015713/ https://ncbi.nlm.nih.gov/pubmed/33737384 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.345397.120 |
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