Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity

Steatosis is a liver lesion reported with numerous pharmaceuticals. Prior studies showed that severe impairment of mitochondrial fatty acid oxidation (mtFAO) constantly leads to lipid accretion in liver. However, much less is known about the mechanism(s) of drug-induced steatosis in the absence of s...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Cell Biol Toxicol
Auteurs principaux: Allard, Julien, Bucher, Simon, Massart, Julie, Ferron, Pierre-Jean, Le Guillou, Dounia, Loyant, Roxane, Daniel, Yoann, Launay, Youenn, Buron, Nelly, Begriche, Karima, Borgne-Sanchez, Annie, Fromenty, Bernard
Format: Artigo
Langue:Inglês
Publié: Springer Netherlands 2020
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8012331/
https://ncbi.nlm.nih.gov/pubmed/32535746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10565-020-09537-1
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires