Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity

Steatosis is a liver lesion reported with numerous pharmaceuticals. Prior studies showed that severe impairment of mitochondrial fatty acid oxidation (mtFAO) constantly leads to lipid accretion in liver. However, much less is known about the mechanism(s) of drug-induced steatosis in the absence of s...

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Publicat a:Cell Biol Toxicol
Autors principals: Allard, Julien, Bucher, Simon, Massart, Julie, Ferron, Pierre-Jean, Le Guillou, Dounia, Loyant, Roxane, Daniel, Yoann, Launay, Youenn, Buron, Nelly, Begriche, Karima, Borgne-Sanchez, Annie, Fromenty, Bernard
Format: Artigo
Idioma:Inglês
Publicat: Springer Netherlands 2020
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8012331/
https://ncbi.nlm.nih.gov/pubmed/32535746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10565-020-09537-1
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