Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity

Steatosis is a liver lesion reported with numerous pharmaceuticals. Prior studies showed that severe impairment of mitochondrial fatty acid oxidation (mtFAO) constantly leads to lipid accretion in liver. However, much less is known about the mechanism(s) of drug-induced steatosis in the absence of s...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Biol Toxicol
Main Authors: Allard, Julien, Bucher, Simon, Massart, Julie, Ferron, Pierre-Jean, Le Guillou, Dounia, Loyant, Roxane, Daniel, Yoann, Launay, Youenn, Buron, Nelly, Begriche, Karima, Borgne-Sanchez, Annie, Fromenty, Bernard
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Netherlands 2020
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8012331/
https://ncbi.nlm.nih.gov/pubmed/32535746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10565-020-09537-1
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados