Cx43 hemichannel microdomain signaling at the intercalated disc enhances cardiac excitability

Cx43, a major cardiac connexin, forms precursor hemichannels that accrue at the intercalated disc to assemble as gap junctions. While gap junctions are crucial for electrical conduction in the heart, little is known about the potential roles of hemichannels. Recent evidence suggests that inhibiting...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: De Smet, Maarten A.J., Lissoni, Alessio, Nezlobinsky, Timur, Wang, Nan, Dries, Eef, Pérez-Hernández, Marta, Lin, Xianming, Amoni, Matthew, Vervliet, Tim, Witschas, Katja, Rothenberg, Eli, Bultynck, Geert, Schulz, Rainer, Panfilov, Alexander V., Delmar, Mario, Sipido, Karin R., Leybaert, Luc
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2021
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8011902/
https://ncbi.nlm.nih.gov/pubmed/33621213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI137752
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