Cx43 hemichannel microdomain signaling at the intercalated disc enhances cardiac excitability

Cx43, a major cardiac connexin, forms precursor hemichannels that accrue at the intercalated disc to assemble as gap junctions. While gap junctions are crucial for electrical conduction in the heart, little is known about the potential roles of hemichannels. Recent evidence suggests that inhibiting...

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Pubblicato in:J Clin Invest
Autori principali: De Smet, Maarten A.J., Lissoni, Alessio, Nezlobinsky, Timur, Wang, Nan, Dries, Eef, Pérez-Hernández, Marta, Lin, Xianming, Amoni, Matthew, Vervliet, Tim, Witschas, Katja, Rothenberg, Eli, Bultynck, Geert, Schulz, Rainer, Panfilov, Alexander V., Delmar, Mario, Sipido, Karin R., Leybaert, Luc
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8011902/
https://ncbi.nlm.nih.gov/pubmed/33621213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI137752
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