Cx43 hemichannel microdomain signaling at the intercalated disc enhances cardiac excitability

Cx43, a major cardiac connexin, forms precursor hemichannels that accrue at the intercalated disc to assemble as gap junctions. While gap junctions are crucial for electrical conduction in the heart, little is known about the potential roles of hemichannels. Recent evidence suggests that inhibiting...

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Bibliografski detalji
Izdano u:J Clin Invest
Glavni autori: De Smet, Maarten A.J., Lissoni, Alessio, Nezlobinsky, Timur, Wang, Nan, Dries, Eef, Pérez-Hernández, Marta, Lin, Xianming, Amoni, Matthew, Vervliet, Tim, Witschas, Katja, Rothenberg, Eli, Bultynck, Geert, Schulz, Rainer, Panfilov, Alexander V., Delmar, Mario, Sipido, Karin R., Leybaert, Luc
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2021
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8011902/
https://ncbi.nlm.nih.gov/pubmed/33621213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI137752
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