Cx43 hemichannel microdomain signaling at the intercalated disc enhances cardiac excitability

Cx43, a major cardiac connexin, forms precursor hemichannels that accrue at the intercalated disc to assemble as gap junctions. While gap junctions are crucial for electrical conduction in the heart, little is known about the potential roles of hemichannels. Recent evidence suggests that inhibiting...

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Udgivet i:J Clin Invest
Main Authors: De Smet, Maarten A.J., Lissoni, Alessio, Nezlobinsky, Timur, Wang, Nan, Dries, Eef, Pérez-Hernández, Marta, Lin, Xianming, Amoni, Matthew, Vervliet, Tim, Witschas, Katja, Rothenberg, Eli, Bultynck, Geert, Schulz, Rainer, Panfilov, Alexander V., Delmar, Mario, Sipido, Karin R., Leybaert, Luc
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8011902/
https://ncbi.nlm.nih.gov/pubmed/33621213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI137752
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