The SH3-binding domain of Cx43 participates in loop/tail interactions critical for Cx43-hemichannel activity

Connexin 43 (Cx43) hemichannels establish local signaling networks via the release of ATP and other molecules, but their excessive opening may result in cell death. Hence, the activity of Cx43-hemichannels ought to be critically controlled. This involves interactions between the C-terminal tail (CT)...

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Bibliographic Details
Published in:Cell Mol Life Sci
Main Authors: Iyyathurai, Jegan, Wang, Nan, D’hondt, Catheleyne, Jiang, Jean X., Leybaert, Luc, Bultynck, Geert
Format: Artigo
Language:Inglês
Published: Springer International Publishing 2017
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6318120/
https://ncbi.nlm.nih.gov/pubmed/29218600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-017-2722-7
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