Endoplasmic reticulum stress sensor IRE1α propels neutrophil hyperactivity in lupus

Neutrophils amplify inflammation in lupus through the release of neutrophil extracellular traps (NETs). The endoplasmic reticulum stress sensor inositol-requiring enzyme 1 α (IRE1α) has been implicated as a perpetuator of inflammation in various chronic diseases; however, IRE1α has been little studi...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Sule, Gautam, Abuaita, Basel H., Steffes, Paul A., Fernandes, Andrew T., Estes, Shanea K., Dobry, Craig, Pandian, Deepika, Gudjonsson, Johann E., Kahlenberg, J. Michelle, O’Riordan, Mary X., Knight, Jason S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2021
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8011900/
https://ncbi.nlm.nih.gov/pubmed/33561013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI137866
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