Endoplasmic Reticulum stress activates the inflammasome via NLRP3-caspase-2 driven mitochondrial damage

Endoplasmic reticulum (ER) stress is observed in many human diseases, often associated with inflammation. ER stress can trigger inflammation through nucleotide-binding domain and leucine-rich repeat containing (NLRP3) inflammsome, which may stimulate inflammasome formation by association with damage...

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Bibliografiska uppgifter
I publikationen:Immunity
Huvudupphovsmän: Bronner, Denise N., Abuaita, Basel H., Chen, Xiaoyun, Fitzgerald, Katherine A., Nuñez, Gabriel, He, Yongqun, Yin, Xiao-Ming, O’Riordan, Mary X.D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4582788/
https://ncbi.nlm.nih.gov/pubmed/26341399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.08.008
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