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IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress

IRE1β is an ER stress sensor uniquely expressed in epithelial cells lining mucosal surfaces. Here, we show that intestinal epithelial cells expressing IRE1β have an attenuated unfolded protein response to ER stress. When modeled in HEK293 cells and with purified protein, IRE1β diminishes expression...

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Veröffentlicht in:J Cell Biol
Hauptverfasser: Grey, Michael J., Cloots, Eva, Simpson, Mariska S., LeDuc, Nicole, Serebrenik, Yevgeniy V., De Luca, Heidi, De Sutter, Delphine, Luong, Phi, Thiagarajah, Jay R., Paton, Adrienne W., Paton, James C., Seeliger, Markus A., Eyckerman, Sven, Janssens, Sophie, Lencer, Wayne I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Rockefeller University Press 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7041686/
https://ncbi.nlm.nih.gov/pubmed/31985747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201904048
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