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IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress
IRE1β is an ER stress sensor uniquely expressed in epithelial cells lining mucosal surfaces. Here, we show that intestinal epithelial cells expressing IRE1β have an attenuated unfolded protein response to ER stress. When modeled in HEK293 cells and with purified protein, IRE1β diminishes expression...
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| Publicado no: | J Cell Biol |
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| Principais autores: | , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Rockefeller University Press
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7041686/ https://ncbi.nlm.nih.gov/pubmed/31985747 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201904048 |
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