Hydroxamate based Selective Macrophage Elastase (MMP-12) Inhibitors and Radiotracers for Molecular Imaging

Macrophage elastase [matrix metalloproteinase (MMP)-12] is the most upregulated MMP in abdominal aortic aneurysm (AAA) and hence MMP-12-targeted imaging may predict AAA progression and rupture risk. Here, we report the design, synthesis and evaluation of three novel hydroxamate-based selective MMP-1...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Gona, Kiran, Toczek, Jakub, Ye, Yunpeng, Sanzida, Nowshin, Golbazi, Arvene, Boodagh, Parnaz, Salarian, Mani, Jung, Jae-Joon, Rajendran, Saranya, Kukreja, Gunjan, Wu, Terence L., Devel, Laurent, Sadeghi, Mehran M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8010999/
https://ncbi.nlm.nih.gov/pubmed/33206510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c01514
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