Novel Arginine-containing Macrocyclic MMP Inhibitors: Synthesis, (99m)Tc-labeling, and Evaluation

Matrix metalloproteinases (MMPs) are involved in tissue remodeling. Accordingly, MMP inhibitors and related radiolabeled analogs are important tools for MMP-targeted imaging and therapy in a number of diseases. Herein, we report design, synthesis, and evaluation of a new Arginine-containing macrocyc...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Ye, Yunpeng, Toczek, Jakub, Gona, Kiran, Kim, Hye-Yeong, Han, Jinah, Razavian, Mahmoud, Golestani, Reza, Zhang, Jiasheng, Wu, Terence L., Ghosh, Mousumi, Jung, Jae-Joon, Sadeghi, Mehran M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6076275/
https://ncbi.nlm.nih.gov/pubmed/30076321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-29941-2
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